Dr. Petukhov laboratory

Department of Medicinal Chemistry and Pharmacognosy

 

Medicinal Chemistry, Chemical Biology, Molecular Modeling, and Drug Discovery

Welcome to Dr. Petukhov laboratory at the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago. We are interested in the development of new methods and biologically orthogonal chemical tools for chemical biology and translation of this knowledge to discovery of novel therapeutically relevant compounds. Our areas of expertise include medicinal chemistry, chemical biology, molecular modeling, and drug discovery.

The current focus of the laboratory is on the development of the Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) method for characterization of multiple binding modes of the ligands in the binding sites of histone deacetylase (HDAC), design and synthesis of novel isoform-selective photoreactive probes (PRPs) to study deacetylase complexes, discovery of novel PRP-based approaches for chromatin immunoprecipitation (ChIP), discovery of novel selective inhibitors of HDACs for cancer and neurological diseases, and discovery of novel inhibitors of hepatitis B (HBV) replication.

We also participate in the projects at the UIC Collaborative Engagement in Novel Therapeutic Research and Enterprise center (UICentre).

Graduate students are invited for rotation and PhD research in medicinal chemistry, chemical biology, and computer-aided drug design. Contact Dr. Pavel Petukhov for more detailed information regarding potential projects.

Prospective graduate students are encouraged to visit Medicinal Chemistry graduate program page.