Chemical Biology, Drug Discovery, and Molecular Modeling
Welcome to Dr. Petukhov laboratory at the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago. We are interested in the development of new methods and biologically orthogonal chemical tools for chemical biology and translation of this knowledge to discovery of novel therapeutically relevant compounds.
The current focus of the laboratory is on the development of the Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) method for characterization of multiple binding modes of the ligands in the binding sites of histone deacetylase (HDAC) and discovery of novel inhibitors of histone deacetylases (for cancer and neurological diseases) and discovery of novel inhibitors of calpain, beta-secretases 1 and 2 (Alzheimer's disease), pantothenate synthetase (tuberculosis), and malate synthase (tuberculosis). Follow the links on the left to learn more about the laboratory.
Graduate students are invited for rotation and PhD research in chemical biology, computer-aided drug design, and medicinal chemistry. Contact Dr. Pavel Petukhov for more detailed information regarding potential projects.
Prospective graduate students are encouraged to visit Medicinal Chemistry graduate program page.